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Sokolovic Sekib

Sokolovic Sekib

University Clinical Center Sarajevo and Medical, Bosnia and Herzegovina

Title: Arterial stiffness: The reality facts from the practice

Biography

Biography: Sokolovic Sekib

Abstract

Introduction and Problem: Theoretically, arterial stiffness is one of the major signs of arterial calcifications associated with arterial hypertension. Researchers have reported that arterial stiffness is related to vascular age, more important than biological age. The purpose of this study is to describe our experience in understanding the clinical importance of arterial stiffness in relation to blood pressure and cardiovascular risk factors.

Methodology & Theoretical approach: An inter and intra observation study using all parameters relevant to arterial stiffness change was utilized during participant observation: patient demographics and cardiovascular risk factors, peripheral blood pressure, central blood pressure, pulse and pulse pressure, hemodynamics and all significant arterial stiffness parameters. All measurements were made on apparatus Agedio. Total of 220 subject were screened.

Results: Our preliminary results have shown that the blood pressure was the major cause of the arterial stiffness values and variability of the vascular aging. Other risk factors had a certain influence, but not as the major determinants. The antihypertensive treatment had a significant impact on decreasing the arterial stiffness measures and indexes.

Conclusion & Significance: The arterial stiffness data obtained from this study are not constant parameter, rather are the reflection of changeable values depending on the blood pressure measures and treatment options. These recommendations should help in better understanding of aging process and vascular arteriosclerosis.

References:

  1. Carlo Palombo, Michaela Kozakova (2016) Arterial stiffness, atherosclerosis and cardiovascular risk: Pathophysiologic mechanisms and emerging clinical indications, Vascular Pharmacology 771:1-7.
  2. N. L. Sehgel, Z. Sun, Z. Hong, W. C. Hunter, M. A. Hill, D. E. Vatner, S. F. Vatner, G. A. Meininger. (2014) Augmented Vascular Smooth Muscle Cell Stiffness and Adhesion When Hypertension Is Superimposed on Aging, Hypertension 65 (2): 370.
  3. Ammar W. Ashor, Jose Lara , Mario Siervo , Carlos Celis-Morales , John C. Mathers (2014) Effects of Exercise Modalities on Arterial Stiffness and Wave Reflection: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. PLOS ONE 9, Issue 10.
  4. Rupert A. Payne, Ian B. Wilkinson, David J. Webb (2010), Arterial stiffness and hypertension: Emerging Concepts, Hypertension 55:9-14.
  5. Stephane Laurent, John Cockcroft , Luc Van Bortel , Pierre Boutouyrie , Cristina Giannattasio , Daniel Hayoz , Bruno Pannier , Charalambos Vlachopoulos , Ian Wilkinson , and Harry Struijker-Boudier on behalf of the European Network for Non-invasive Investigation of Large Arterie. (2006) Expert consensus document on arterial stiffness: methodological issues and clinical applications. European Heart Journal 27, 2588–2605