Peter J Blankestijn
University Medical Center Utrecht, the Netherlands
Title: Renal denervation: Present situation and perspectives for the future.
Biography
Biography: Peter J Blankestijn
Abstract
Statement of the Problem:
Renal denervation has been introduced for the treatment of resistance hypertension. There is considerable theoretical and experimental evidence that renal denervation may be an effective antihypertensive treatment. Presently available clinical evidence in conflicting, but large randomized controlled trials are underway and first results will be presented later in 2017.
In this presentation the present status on safety and efficacy and considerations for the future of renal denervation in hypertensive patients will be discussed. It is now clear that poor medication adherence is a common finding is resistant hypertension patients. How this interacts with renal denervation will be addressed. Finally, possible other patient groups that may benefit of renal denervation are mentioned as well.
References:
1: de Jager RL, Casteleijn NF, de Beus E, Bots ML, Vonken EE, Gansevoort RT, Blankestijn PJ. Catheter-based renal denervation as therapy for chronic severe kidney-related pain. Nephrol Dial Transplant. 2017 Jun 22.
2: Mahfoud F, Schmieder RE, Azizi M, Pathak A, Sievert H, Tsioufis C, Zeller T, Bertog S, Blankestijn PJ, Böhm M, Burnier M, Chatellier G, Durand Zaleski I, Ewen S, Grassi G, Joner M, Kjeldsen SE, Lobo MD, Lotan C, Felix Lüscher T, Parati G, Rossignol P, Ruilope L, Sharif F, van Leeuwen E, Volpe M, Windecker S, Witkowski A, Wijns W. Proceedings from the 2nd European Clinical Consensus Conference for device-based therapies for hypertension: state of the art and considerations for the future. Eur Heart J. 2017 May 5. doi: 10.1093/eurheartj/ehx215. [Epub ahead of print] PubMed PMID: 28475773.
3: Sanders MF, van Doormaal PJ, Beeftink MM, Bots ML, Fadl Elmula FE, Habets J,Hammer F, Hoffmann P, Jacobs L, Mark PB, Persu A, Renkin J, Roditi G, Spiering W,Staessen JA, Taylor AH, Verloop WL, Vink EE, Vonken EJ, Voskuil M, Leiner T, Blankestijn PJ; European Network COordinating research on Renal Denervation(ENCOReD) Consortium. Renal artery and parenchymal changes after renal denervation: assessment by magnetic resonance angiography. Eur Radiol. 2017 Mar 7. doi: 10.1007/s00330-017-4770-7. [Epub ahead of print] PubMed PMID: 28271154.
4: de Jager RL, de Beus E, Beeftink MM, Sanders MF, Vonken EJ, Voskuil M, van Maarseveen EM, Bots ML, Blankestijn PJ; SYMPATHY Investigators. Impact of Medication Adherence on the Effect of Renal Denervation: The SYMPATHY Trial. Hypertension. 2017 Apr;69(4):678-684.