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A.J. van Ballegooijen

A.J. van Ballegooijen

VU University, Amsterdam, The Netherlands

Title: The joint association of vitamin D and vitamin K with incident hypertension and cardiovascular health

Biography

Biography: A.J. van Ballegooijen

Abstract

Statement of the Problem: Cardiovascular disease and osteoporosis are major age-related causes of morbidity and premature death that occur among older adults. Emerging evidence suggests that calcium from bone is deposited in the arteries. This leads to calcification in valves and vessels, which is associated with a 3-4 fold higher risk of coronary heart disease. Calcium and vitamin D supplementation is frequently advised in older adults for the prevention of osteoporosis and to reduce the risk of fractures and falls. However, recent RCT's showed that individuals taking calcium and vitamin D were at higher risk of cardiovascular disease. The widespread use of vitamin D and calcium supplements, and the fortification of vitamin D in food products, underscores the need for further investigation.
Recent studies show that vitamin K reduces coronary calcification and cardiovascular disease. New evidence suggests that vitamin K combined with vitamin D can lower vascular calcification more than the effect of either alone. This presentation will give a brief overview of the current body of evidence of joint associations between vitamin D and vitamin K with hypertension and underlying mechanisms of cardiovascular disease in multiple cohort studies.

Conclusion & significance: The combination of low vitamin D and K status is associated with increased blood pressure and might play a role in development of hypertension and cardiovascular disease risk. These promising results of the joint associations of vitamin D and vitamin K in relation to cardiovascular health stimulate further follow-up studies to better understand the clinical implications of this relationship to promote cardiovascular health.

References:

  1. Van Ballegooijen AJ, Rhee EP, Elmariah S, de Boer IH, Kestenbaum B., (2015), Renal Clearance of Mineral Metabolism Biomarkers. J Am Soc Nephrol, ASN 2014, 21253.
     
  2. Van Ballegooijen, AJ, Gansevoort, RT, Lambers-Heerspink H, de Zeeuw D, Visser M, Brouwer IA, Kema IP, de Borst MH, Bakker SJ, Joosten MM.(2015), Plasma 1, 25-Dihydroxyvitamin D and the Risk of Developing Hypertension, the Prevention of Renal and Vascular End-Stage Disease Study. Hypertension; 66(3):563-70.
     
  3. Van Ballegooijen AJ, Kestenbaum B, Sachs MC, de Boer IH, et al.,(2014), Association of 25-hydroxyvitamin D and Parathyroid Hormone with Incident Hypertension: The Multi-Ethnic Study of Atherosclerosis J Am Coll Cardiol.; S0735-1097(14)00300-3.
     
  4. Van Ballegooijen AJ, Visser M, Cothc MF, Arai AE, et al., (2013) Serum Vitamin D and Parathyroid Hormone in Relation to Cardiac Structure and Function: the ICELAND-MI Substudy of AGES-Reykjavik. J Clin Endocrinol Metab.; 98: 2544-2552.
     
  5. Van Ballegooijen AJ, Reinders I, Visser M, Brouwer IA., (2013), Parathyroid hormone and cardiovascular disease events: A systematic review and meta-analysis of prospective studies, Am Heart J.; 165(5):655-64, 664.e1-5.